Testing of semisolids with paddle method (USP 2)
Testing so-called semisolids - such as ointments, creams, lotions and gels - is often a difficult and time-consuming task. The so-called "Vertical Diffusion Cell" - also called the "Franz Cell" - is often used for this purpose, but it has to be tempered and flowed through at great expense! The "Immersion-Cell" is an alternative described by the USP, Chapter <1724> for testing semi-isolables. Despite the easy use with the USP-Apparatus 2 (Paddles) it is less well known.
The advantages of the Immersion-Cell are:
- Can be used in any dissolution tester (also from other manufacturers) with a 200mL - Small Volume Paddle Conversion Kit with 200mL Flat Bottom Vessel.
- Easy filling of the Semisolids into the Immersion-Cell. The desired volume is adjustable.
- Easy membrane attachment.
- Easy tempering with the water bath of the dissolution tester.
- Release with the paddle method, no susceptible flow principle.
- Sampling as usual with the paddle method (mechanical or automated).
PVDF, Tuffryn Polysulfone and Strat-M membranes are available as membranes.
Further information can be found under Information.
Do you have any questions? We will be happy to help you personally. Please use our contact center to write us an email or give us a call.